A semiempirical study on inhibition of catechol O-methyltransferase by substituted catechols
- 1 January 1998
- journal article
- Published by Springer Nature in Journal of Computer-Aided Molecular Design
- Vol. 12 (3) , 301-307
- https://doi.org/10.1023/a:1007965026738
Abstract
Catechol and endogenous catechol derivatives are readily methylated by catechol O-methyltransferase (COMT). In contrast, many catechol derivatives possessing electronegative substituents are potent...Keywords
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