THE PERMISSIVE ROLE OF HYPERTHERMIA IN THE DISAGGREGATION OF BRAIN POLYSOMES BY l‐DOPA OR d‐AMPHETAMINE1
- 1 April 1977
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 28 (4) , 779-782
- https://doi.org/10.1111/j.1471-4159.1977.tb10627.x
Abstract
Abstract— l‐DOPA or d‐amphetamine administration disaggregates brain polyribosomes in animals maintained in an environment warm enough (26°C) so that the drugs concurrently elevate their body temperatures to above 39°C. The production of equivalent hyperthermia (by keeping control rats at ambient temperatures of 40–44° C) does not cause similar disaggregation of brain polysomes. Hence, the role of hyperthermia in the drug‐induced disaggregation is permissive.This publication has 18 references indexed in Scilit:
- ROLE OF RIBONUCLEASE ACTION IN PHENYLALANINE‐INDUCED DISAGGREGATION OF RAT CEREBRAL POLYRIBOSOMESJournal of Neurochemistry, 1976
- IN VIVO INHIBITION OF RAT BRAIN PROTEIN SYNTHESIS BY l‐DOPAJournal of Neurochemistry, 1974
- L‐Dopa, Polysomal Aggregation and Cerebral Synthesis of ProteinPublished by Wiley ,1974
- IN VIVO EFFECTS OF AMPHETAMINE ON METABOLITES AND METABOLIC RATE IN BRAINJournal of Neurochemistry, 1973
- Ultrastructural evidence against in vivo disaggregation of brain polyribosomes after administration of L-dopa or phenylalanineJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1973
- Release of Brain Dopamine as the Probable Mechanism for the Hypothermic Effect of D-AmphetamineNature, 1972
- The effects of D-amphetamine and related drugs on colonic temperatures of rats kept at various ambient temperaturesLife Sciences, 1972
- Dopamine: Mediator of Brain Polysome Disaggregation after L-DopaScience, 1972
- L-Dopa: Disaggregation of Brain Polysomes and Elevation of Brain TryptophanScience, 1971
- Thermoregulation: Effects of Environmental Temperature on Turnover of Hypothalamic NorepinephrineScience, 1969