Tst-1/Oct-6/SCIP regulates a unique step in peripheral myelination and is required for normal respiration.
Open Access
- 15 July 1996
- journal article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 10 (14) , 1751-1762
- https://doi.org/10.1101/gad.10.14.1751
Abstract
The terminal differentiation of myelinating glia involves complex interactions that culminate in the formation of myelin. The POU domain transcription factor Tst-1/Oct-6/SCIP is expressed transiently during myelination, and we report here that it has a critical role in this developmental process. Deletion of the Tst-1/Oct-6/SCIP gene produces a severe defect in peripheral myelination by arresting Schwann cell maturation before axonal wrapping. Unexpectedly, the activation of major myelin-specific genes appears to be unaffected by the Tst-1/Oct-6/SCIP mutation, demonstrating that multiple, independently regulated events are required for terminal differentiation of Schwann cells. In addition, aberrant differentiation and migration of specific neurons in Tst-1/Oct-6/SCIP mutant homozygotes is associated with a fatal breathing defect, providing a model for investigating the regulation of pulmonary homeostasis.Keywords
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