High Incidence of Ependymomas Induced by BK Virus, a Human Papovavirus: Brief Communication2
- 1 November 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 59 (5) , 1561-1564
- https://doi.org/10.1093/jnci/59.5.1561
Abstract
Ependymomas were produced in 44 of 50 Syrian golden hamsters and in 9 of 31 outbred Swiss mice inoculated intracerebrally with high-titer, purified BK virus (BKV). Tumors contained a T-antigen that reacted with BKV-specific T-antibody in immunofluorescence and complement-flxatlon tests. A proportion of tumor-bearing animals had antibodies to BKV T-antigen in their sera. BKV could be rescued from two tumor cell lines by Sendal virus-mediated fusion with Yero cells. A low, or lack of, oncogenic activity was displayed by BKV inoculated sc, ip, or iv.Keywords
This publication has 3 references indexed in Scilit:
- Induction of Tumors in Syrian Hamsters by a Human Renal Papovavirus, RF Strain2JNCI Journal of the National Cancer Institute, 1976
- Hamster Ependymomas Produced by Intracerebral Inoculation of a Human Papovavirus (MMV)JNCI Journal of the National Cancer Institute, 1976
- Malignant Transformation of Hamster Brain Cells in Vitro by Human Papovavirus BK 2JNCI Journal of the National Cancer Institute, 1976