Stereoselective α-Alkylation of New Chiral Auxiliaries: An Access to Enantiomerically Pure α- and α,β-Substituted β-Amino Acids
- 1 November 1999
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1999 (11) , 1838-1840
- https://doi.org/10.1055/s-1999-2925
Abstract
New bicyclic heterocycles 5, which are potentially useful for the enantioselective synthesis of substituted β-amino acids, have been synthesized. A study on the α-alkylation of these chiral auxiliaries is presented. An optically pure β-amino acid was obtained in excellent yield from its masked chiral derivative 6a.Keywords
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