Drug Disposition in Old Age

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Abstract
To the Editor: Greenblatt and his co-workers (May 6 issue)1 have indicated an important role for reduced organ blood flow in the pharmacokinetic handling of drugs by the elderly patient; these authors have made a major contribution to these investigations. But when all is said and done, most drug therapy in old people, with few exceptions, can be started at the lower recommended dose (or with longer intervals between doses). This practice would be subject to clinical surveillance and titration or, if available, to drug assays.2 The watchword in prescribing for the elderly could be: Be thrifty with periodic . . .