Trichothecenes, 1: The Synthesis of 4-Deoxyverrucarol from Verrucarol and Diacetoxyscirpenol
- 1 May 1984
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 47 (3) , 514-519
- https://doi.org/10.1021/np50033a019
Abstract
Deoxyverrucarol (4) was synthesized for use in studies for the preparation and development of monoclonal antibodies for trichothecenes. Both verrucarol (1) [from Myrothecium verrucaria] and anguidine (2) were converted to deoxyverrucarol (DOVE) (4) by deoxygenation at C3 and at C3 and C4, respectively. [The extremely high acute toxicity of the trichothecenes has caused investigators to seek methods that would effectively dilute or nullify the toxic effects of these substances.].This publication has 2 references indexed in Scilit:
- Isolation and characterization of the trichoverroids and new roridins and verrucarinsThe Journal of Organic Chemistry, 1982
- Die Konstitution von DiacetoxyscirpenolHelvetica Chimica Acta, 1965