The effect of endothelin, neuropeptide Y, calcitonin gene‐related peptide and substance P on neutrophil functions

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Abstract
Neuropeptides are putative mediators of inflammation. At physiological concentrations substance P has been shown to prime polymorphonuclear neutrophil granulocyte (PMN) chemiluminescence (CL). In the present study we show also that both endothelin and neuropeptide Y (NPY), but not calcitonin gene‐related peptide (CGRP) are able to prime PMN oxidative metabolism. At similar nanomolar concentrations SP and endothelin (but not NPY) also primed formyl‐methionyl‐leucyl‐phenylalanine (fMLP)‐induced rises of cytosolic calcium. On the other hand, NPY caused a direct and dose‐related increase of cytosolic calcium concentrations. None of the mentioned neuropeptides primed PMN aggregation or directly induced CL, aggregation or chemotaxis over a wide range of concentrations (1 fm‐1 μm).

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