Autorhythmic Contractions of the Postnatal Rabbit Testicular Capsule and its Response to Prostaglandins, Epinephrine and Acetyicholine

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Abstract
Autorhythmic contractions of the rabbit testicular capsule were measured in vivo and in vitro in preparations from animals 2-18 wk of age. The response of the testicular preparations to prostaglandin (PG)F2.alpha., PGE1, epinephrine and acetylcholine (ACH) was determined and log dose-response curves plotted. Spontaneous autorhythmic contractions occur in vivo and in vitro throughout postnatal development, the amplitude of the contractions increases while the mass of the testis and the thickness of the testicular capsule increases, and the relative response to PGF2.alpha., epinephrine and ACH remains constant throughout postnatal development. The response of the testicular capsule to PGE1 became progressively more inhibitory at higher concentrations throughout postnatal development, which may be indicative of the development of adenylcyclase activity within the testicular tissues.

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