Disposable Smart Lab on a Chip for Point-of-Care Clinical Diagnostics
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- 8 November 2004
- journal article
- Published by Institute of Electrical and Electronics Engineers (IEEE) in Proceedings of the IEEE
- Vol. 92 (1) , 154-173
- https://doi.org/10.1109/jproc.2003.820548
Abstract
This paper presents the development of a disposable plastic biochip incorporating smart passive microfluidics with embedded on-chip power sources and integrated biosensor array for applications in clinical diagnostics and point-of-care testing. The fully integrated disposable biochip is capable of precise volume control with smart microfluidic manipulation without costly on-chip microfluidic components. The biochip has a unique power source using on-chip pressurized air reservoirs, for microfluidic manipulation, avoiding the need for complex microfluidic pumps. In addition, the disposable plastic biochip has successfully been tested for the measurements of partial oxygen concentration, glucose, and lactate level in human blood using an integrated biosensor array. This paper presents details of the smart passive microfluidic system, the on-chip power source, and the biosensor array together with a detailed discussion of the plastic micromachining techniques used for chip fabrication. A handheld analyzer capable of multiparameter detection of clinically relevant parameters has also been developed to detect the signals from the cartridge type disposable biochip. The handheld analyzer developed in this work is currently the smallest analyzer capable of multiparameter detection for point-of-care testing.Keywords
This publication has 61 references indexed in Scilit:
- Analysis and experiment of centrifugal force for microfluidic ELISA CD platformPublished by Institute of Electrical and Electronics Engineers (IEEE) ,2010
- Chaotic Mixer for MicrochannelsScience, 2002
- Microfluidics Section: Design and Fabrication of Integrated Passive Valves and Pumps for Flexible Polymer 3-Dimensional Microfluidic SystemsBiomedical Microdevices, 2002
- Mélange passif dans les microcanaux : fabrication et expérienceMécanique & Industries, 2001
- Responsive biomimetic hydrogel valve for microfluidicsApplied Physics Letters, 2001
- A Rapid Vortex Micromixer for Studying High-Speed Chemical ReactionsPublished by Springer Nature ,2001
- Structurally Programmable Microfluidic SystemsPublished by Springer Nature ,2000
- Hydrophobic microfluidicsProceedings of SPIE, 1999
- Droplet-based nano/picoliter mixer using hydrophobic microcapillary ventPublished by Institute of Electrical and Electronics Engineers (IEEE) ,1999
- Microfluidic flow control using selective hydrophobic patterningPublished by SPIE-Intl Soc Optical Eng ,1997