STUDIES ON GALLIUM ACCUMULATION IN INFLAMMATORY LESIONS .2. UPTAKE BY STAPHYLOCOCCUS-AUREUS - CONCISE COMMUNICATION

Google Scholar
  • 1 January 1978
    • journal article
    • research article
    • Vol. 19  (1) , 44-47
Abstract
67Ga was demonstrated to be taken up in significant amounts by a number of common microorganisms. The mechanism of 67Ga uptake was studied in S. aureus. It apparently involves 2 separate processes. One is insensitive to temperature or metabolic inhibitors and is not inhibited by a high concentration of nonradioactive Ga. This process probably operates through nonspecific binding of 67Ga to components of S. aureus. The 2nd process is not inhibited by metabolic inhibitors either, but it is temperature-sensitive and is inhibited by high concentrations of stable Ga. This component of the 67Ga uptake is most likely due to a carrier-mediated transport system (facilitated transfer).