Application of Homeostatic Principles to the Management of Nephrotic Patients

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Abstract
ATTENTION has been called to the fact that patients who have lost most of their normal capacity to eliminate water, potassium and phosphate as a consequence of severe renal damage may nonetheless retain a very satisfactory ability to take and eliminate considerable amounts of sodium and chloride.1 By contrast, as is well known, patients with childhood nephrosis may fail to eliminate dietary sodium chloride and water and may become markedly edematous despite the fact that their renal function, as judged by conventional clearance measurements and by their capacity to handle other ordinary dietary constituents such as potassium and phosphate, is . . .