p16 INK4a hypermethylation and p53, p16 and MDM2 protein expression in Esophageal Squamous Cell Carcinoma
Open Access
- 13 April 2010
- journal article
- Published by Springer Nature in BMC Cancer
- Vol. 10 (1) , 138
- https://doi.org/10.1186/1471-2407-10-138
Abstract
Tumor suppressor genes p53 and p16INK4a and the proto-oncogene MDM2 are considered to be essential G1 cell cycle regulatory genes whose loss of function is associated with ESCC carcinogenesis. We assessed the aberrant methylation of the p16 gene and its impact on p16INK4a protein expression and correlations with p53 and MDM2 protein expressions in patients with ESCC in the Golestan province of northeastern Iran in which ESCC has the highest incidence of cancer, well above the world average.Keywords
This publication has 47 references indexed in Scilit:
- Cancer incidence and mortality in IranAnnals of Oncology, 2008
- Aberrant DNA Methylation ofP16, MGMT, andhMLH1Genes in Combination withMTHFRC677T Genetic Polymorphism in Esophageal Squamous Cell CarcinomaCancer Epidemiology, Biomarkers & Prevention, 2008
- Oesophageal squamous cell carcinoma may develop within a background of accumulating DNA methylation in normal and dysplastic mucosaGut, 2007
- Chronic Oral Exposure to Inorganic Arsenate Interferes with Methylation Status of p16INK4a and RASSF1A and Induces Lung Cancer in A/J MiceToxicological Sciences, 2006
- p16 expression in Barrett's esophagus and esophageal adenocarcinoma: association with genetic and epigenetic alterationsCancer Letters, 2004
- Genetic and epigenetic alterations as hallmarks of the intricate road to cancerOncogene, 2003
- Hypermethylation of the p16 Gene and Lack of p16 Expression in HepatoblastomaLaboratory Investigation, 2003
- Distinct pattern of TP53 mutations in squamous cell carcinoma of the esophagus in IranOncogene, 2001
- Hypomethylation and increased gene expression of p16INK4a in primary and metastatic breast carcinoma as compared to normal breast tissueOncogene, 1998
- p53 in growth control and neoplasiaBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1996