The Observation on the Electron-microscopic Pictures of Cancer Cells Under The Actions of Chemotherapeutic Agents

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Abstract
Changes in fine structure of Yoshida ascites sarcoma cells and Ehrlich ascites hepatoma cells produced by several anticancer remedies (Citral, nitromin, sarcomycin, carcinophyllin, chromo-mycin, Azan, PCMB, and colchicine) were studied. The localities of the points of attack upon tumor cells by these remedies are quite different. Nitromin causes changes in fine structure of tumor cells. Azan and sarcomycin come next to nitromin in the order of effectiveness. Carcinophyllin and chromomycin have moderate effects, localized in the cytoplasm rather than nucleus. Citral causes changes in the nuclear membrane and nucleolus, and in the chromatin substance of the nucleus. Changes in the endoplasmic reticulum are much more remarkable than those of the mitochondria. PCMB damages mitochondria almost exclusively. A potential combination of these two kinds of remedies, aldehydes and PCMB, is discussed.

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