Interactions of the 4-quinolones with other antibacterials
- 1 July 1989
- journal article
- research article
- Published by Microbiology Society in Journal of Medical Microbiology
- Vol. 29 (3) , 221-227
- https://doi.org/10.1099/00222615-29-3-221
Abstract
The effect of sub-inhibitory concentrations of 16 antibacterials on the bactericidal activity of the 4-quinolones nalidixic acid, ciprofloxacin and ofloxacin against Escherichia coli KL16 in nutrient broth was investigated. Sub-inhibitory concentrations of nifampicin, clindamycin, chloramphenicol, erythromycin or tetracycline antagonised the bactericidal activity of the 4-quinolones. Conversely, all seven aminoglycosides tested enhanced the bactericidal activity of the 4-quinolones whereas the cell wall antagonists, azlocillin, mezlocillin, ceftazidime and vancomycin had no effect on the bactericidal activity of the 4-quinolones.This publication has 11 references indexed in Scilit:
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