Synthesis and mutagenicity of 10-azabenzo[a]pyrene-4,5-oxide and other pentacyclic aza-arene oxides.

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Abstract
Aza-arene oxides, dibenz [a, j] acridine-5, 6-oxide, dibenz [a, h] acridine-12, 13-oxide, dibenz [c, h] acridine-5, 6-oxide, and 10-azabenzo [a] pyrene-4, 5-oxide were synthesized and their mutagenic activity to Salmonella typhimurium strains TA 98 and TA 100 was tested.

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