Mast cells in the development of adaptive immune responses
Top Cited Papers
- 20 January 2005
- journal article
- review article
- Published by Springer Nature in Nature Immunology
- Vol. 6 (2) , 135-142
- https://doi.org/10.1038/ni1158
Abstract
Mast cells are so widely recognized as critical effector cells in allergic disorders and other immunoglobulin E–associated acquired immune responses that it can be difficult to think of them in any other context. However, mast cells also can be important as initiators and effectors of innate immunity. In addition, mast cells that are activated during innate immune responses to pathogens, or in other contexts, can secrete products and have cellular functions with the potential to facilitate the development, amplify the magnitude or regulate the kinetics of adaptive immune responses. Thus, mast cells may influence the development, intensity and duration of adaptive immune responses that contribute to host defense, allergy and autoimmunity, rather than simply functioning as effector cells in these settings.Keywords
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