Chromosome Studies of a Transplanted and a Primary Canine Venereal Sarcoma2

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Abstract
An experimentally transplanted, canine venereal sarcoma in the fourth and fifteenth passages and a primary venereal sarcoma with multiple metastases were found to have nearly identical karyotypes. There were 59 chromosomes in most tumor cells, with 15 metacentrics or submetacentrics and 44 acrocentrics. Both chromatids of the long arm of one large submetacentric chromosome showed marked negative heteropyknosis. These 2 tumors originated in different parts of Pennsylvania, and the chromosome complement is very similar to that reported for spontaneous canine venereal tumors in Japan. The similarity of the karyotype of the experimentally transplanted tumor to that of the primary neoplasms suggests that the latter may also be transplanted tumors, propagated spontaneously in the dog population by passage of intact tumor cells during sexual contact.

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