The Biological Activity of Dimeric Testosterone, a New Long-Acting Androgen, and of Testosterone Enanthate in the Castrated Male Rat

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Abstract
The long-term effect of single intramuscular injections of various doses of dimeric testosterone and of testosterone enanthate into castrated male rats upon serum testosterone, luteinizing hormone (LH), pituitary LH, and on the weight of the seminal vesicles, the ventral prostate and the levator ani muscle, was investigated. The effect of the enanthate was characterized by a rapid onset and a protracted androgenic action and a suppression of serum LH, while the dimeric testosterone brought about only a moderate but very even depot effect. The injection of 5 mg of the dimeric testosterone caused a positive feedback effect upon LH release for 16 weeks. The results indicate that the dimeric testosterone may exert its hormonal effects as intact ester.