Cellular Responses to Combinations of Hyperthermia and Radiation

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Abstract
The 2 principal rationales for applying hyperthermia in cancer therapy are that the S phase, which is relatively radioresistant, is the most sensitive phase to hyperthermia, and can be selectively radiosensitized by combing hyperthermia with X-radiation; the cycling tumor cells in S phase which would normally survive an X-ray dose could be killed by subjecting these cells to hyperthermia; and the relatively radioresistant hypoxic cells in the tumor may be selectively destroyed by combinations of hyperthermia and X-irradiation. Both of these rationales were mentioned as reasons for using high LET [linear energy transfer] irradiation in cancer therapy. Where such irradiation may be of use, hyperthermia may also be advantageous. [Chinese hamster ovary cells were used in this study.].