Acyclovir treatment of herpes zoster infections. Use in children undergoing bone marrow transplantation

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Abstract
Three patients in whom herpes zoster infections developed following bone marrow transplantation were treated with acyclovir. The patients experienced pain relief within 24 h of starting treatment. The progression of their lesions halted within 1, 2 and 4 days of therapy, respectively, and healed completely within 2 wk of therapy. Pharmacokinetic studies indicated that acyclovir plasma concentration-time profiles approximated biexponential equations. The drug half-lives were 3.91, 3.83 and 3.40 h, respectively. Acyclovir was not myelotoxic and may be helpful in aborting varicella-zoster virus infections in bone marrow transplant recipients.