Age-Dependent Accuracy of Helicobacter pylori Antibody Assays for Adults, with Special Emphasis on Atrophic Gastritis
- 1 November 2004
- journal article
- Published by American Society for Microbiology in Clinical and Vaccine Immunology
- Vol. 11 (6) , 1185-8
- https://doi.org/10.1128/cdli.11.6.1185-1188.2004
Abstract
The accuracy of Helicobacter pylori antibody assays for 561 consecutive adult outpatients who had undergone gastroscopy was studied. The sensitivity of an immunoglobulin G test was 99 to 100% for all age groups, but the specificity declined by age group, from 99% for those aged 15 to 49 years to 75% for those aged ≥65 years. The exclusion of false-positive results for patients with atrophic gastritis improved the specificity to 93 to 97% for the older age groups.Keywords
This publication has 23 references indexed in Scilit:
- Current concepts in the management of Helicobacter pylori infection—The Maastricht 2‐2000 Consensus ReportAlimentary Pharmacology & Therapeutics, 2002
- Evaluation of a Single-Step Serological Assay for Laboratory Diagnosis of Helicobacter pylori InfectionEuropean Journal of Clinical Microbiology & Infectious Diseases, 2002
- Atrophic gastritis and Helicobacter pylori infection in outpatients referred for gastroscopyGut, 2000
- Diagnosis of Helicobacter pylori Infection in Patients with Atrophic Gastritis: Comparison of Histology, 13C-Urea Breath Test, and SerologyScandinavian Journal of Gastroenterology, 2000
- Accuracy of Seven Different Tests for the Diagnosis ofHelicobacter pyloriInfection and the Impact of H2-Receptor Antagonists on Test ResultsScandinavian Journal of Gastroenterology, 1998
- Helicobacter Pylori Serology in Chronic Gastritis with Antral Atrophy and Negative Histology for Helicobacter-Like OrganismsJournal of Clinical Gastroenterology, 1996
- Diagnostic value of decreasing IgG, IgA, and IgM antibody titres after eradication of Helicobacter pyloriThe Lancet, 1992
- Screening dyspepsia by serology to Helicobacter pyloriThe Lancet, 1991
- The Sydney System: Histological divisionJournal of Gastroenterology and Hepatology, 1991
- Histological Aspects ofCampylobacter pyloriColonisation and Infection of Gastric and Duodenal MucosaScandinavian Journal of Gastroenterology, 1988