Kainic Acid Lesions of the Striatum Dissociate Amphetamine and Apomorphine Stereotypy: Similarities to Huntingdon's Chorea

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Abstract
Kainic acid lesion of cell bodies in the dorsal striatum enhanced the stereotypy-producing effects ofd-amphetamine without affecting the stereotypy produced by the direct receptor agonist apomorphine. This pattern of results parallels that found in patients suffering from Huntington's chorea, thus strengthening the parallels between the kainic acid animal model and the human disease state initially suggested on biochemical grounds. The present results further suggest a dissociation of the mechanisms involved in the production of stereotypy by these two drugs, perhaps in terms of differential involvement of the striato-nigral negative feedback loop.