A New Method of Synthesis of 4-N-Alkyl Substituted Cytosine Derivatives Via 4-N-Arylsulfonyl or Alkylsulfonyl Intermediates
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 6 (1-2) , 269-272
- https://doi.org/10.1080/07328318708056202
Abstract
4-N-p-Toluenesulfonyl and 4-N-methanesulfonyl cyto-sine derivatives are easily prepared from O-protected cyto-sine nucleosides and corresponding sulfonyl chlorides and then converted in high yields into 4-N-alkyl derivatives by treatment with 1° amines under moderate conditions.Keywords
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