Histological Localization of Phosphorothioate Oligodeoxynucleotides in Normal Rodent Tissue
- 1 July 1997
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 16 (7-9) , 1761-1764
- https://doi.org/10.1080/07328319708006272
Abstract
The distribution of phosphorothioate oligodeoxynucleotides (P=S ODN) in rodent tissues was studied in vivo using three histological methods: direct fluorescence microscopy; immunohistochemistry; and autoradiography. All three methods gave essentially the same pattern of oligonucleotide localization in the tissues studied, and the histological results correlate well with those from radiochemical and biochemical studies of P=S ODN distribution.Keywords
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