Mitochondrial degeneration after organic phosphate poisoning in prosimian primates
- 1 January 1977
- journal article
- research article
- Published by Springer Nature in Cell and tissue research
- Vol. 175 (4) , 459-465
- https://doi.org/10.1007/bf00222412
Abstract
The degenerative reaction of mitochondria to tricresylphosphate (TCP) poisoning in spinal ganglion cells of Slow Loris (Nycticebus coucang coucang) were studied with the electron microscope. In neurones of animals treated with TCP, mitochondria display various stages of alterations which confirm mitochondrial involvement in TCP poisoning. The role of degenerated mitochondria in the formation of neuronal lipofuscin is discussed. It is suggested that the lipofuscin granule is a metabolic product inherently related to mitochondrial degeneration, irrespective of the primary cause: ageing or intoxication.This publication has 20 references indexed in Scilit:
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