Instrumental variables in the evaluation of diagnostic test procedures when the true disease state is unknown
- 1 July 1988
- journal article
- research article
- Published by Wiley in Statistics in Medicine
- Vol. 7 (7) , 739-744
- https://doi.org/10.1002/sim.4780070703
Abstract
We explore the estimation of sensitivity and specificity of diagnostic tests when the true disease state is unknown. Instrumental variables which subdivide the patient population are used. A logistic model, relating these instrumental variables to the (unknown) true disease state is proposed. It is shown that this procedure allows the goodness-of-fit to the resulting model to be tested.Keywords
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