A screening method for vasodilator drugs

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Abstract
The use of the isolated perfused central artery of the rabbit ear for screening vasodilator drugs is described. The effects of these drugs are shown by reduction of vasoconstrictor responses to intermittent sympathetic stimulation or to injections of noradrenaline or histamine or by reduction of vascular spasms produced by continuous sympathetic stimulation or infusion of 5-hydroxytryptamine. The relative potencies of the vasodilators used against intermittent sym- pathetic stimulation, in order are: adenosine = sodium nitroprusside = CIBA 31,531-Ba [5-amino-l-(l-methylpiperid-4-yl)- 3-(pyrid-4-y1) pyrazole] > glyceryl trinitrate > papaverine = amino-phylline > dipyridamole » sodium nitrite = hydrallazine.

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