Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies
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- 5 March 2010
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 327 (5970) , 1223-1228
- https://doi.org/10.1126/science.1182228
Abstract
Sestrin and the Consequences of Aging: The protein kinase TOR (target of rapamycin) plays key roles in the control of fundamental biological processes, including growth, metabolism, aging, and immune function. Sestrin proteins show increased abundance in response to stress and have been implicated in control of TOR activity. Lee et al. (p. 1223 ; see the Perspective by Topisirovic and Sonenberg ) characterized Drosophila fruit flies lacking sestrins. Sestrins were implicated in a negative feedback loop in which the abundance of sestrins is controlled by TOR activity with sestrins concomitantly also inhibiting activity of TOR. Furthermore, flies lacking sestrins showed accumulation of fat, muscle degeneration, and heart abnormalities similar to those that plague aging humans with a sedentary life-style.Keywords
This publication has 31 references indexed in Scilit:
- 4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in DrosophilaCell, 2009
- Insulin regulation of heart function in aging fruit fliesNature Genetics, 2004
- TOR Pathway: Linking Nutrient Sensing to Life SpanScience of Aging Knowledge Environment, 2004
- Upstream and downstream of mTORGenes & Development, 2004
- Regeneration of Peroxiredoxins by p53-Regulated Sestrins, Homologs of Bacterial AhpDScience, 2004
- Insulin/IGF and target of rapamycin signaling: a TOR de force in growth controlTrends in Cell Biology, 2003
- Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viabilityOncogene, 2002
- Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in DrosophilaScience, 2002
- PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genesOncogene, 1999
- Electron Microscope Studies on Aging Drosophila melanogaster III. Flight MuscleJournal of Gerontology, 1970