Stimulation of Mouse Megakaryocyte Endomitosis by Plasma from Thrombocytopenic Rats

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Abstract
Injection of plasma from thrombocytopenic donor rats resulted in an increase in the endomitotic index of megakaryocytes of recipient mice 32 h after the initial treatment with plasma. A dose-response relationship was suggested between the amount of plasma administered and the degree of stimulation of megakaryocytopoiesis. An agent capable of stimulating megakaryocytopoiesis is released in response to thrombocytopenia and this factor can be successfully transferred between species. The assumption that the increase in peripheral platelet numbers and in platelet labeling after administration of presumptive TSF [thrombocytopoiesis-stimulating factor] occurs via stimulation of megakaryocytopoiesis was substantiated.

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