Platelet Aggregation and Adhesiveness in Classical Factor X Deficiency and in the Abnormal Factor X (Factor X Friuli) Coagulation Disorder

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Abstract
Platelet aggregation to common inductors and to Ristocetin, Thrombo-fax and Ionophore is normal in congenital factor X deficiency and in factor X Friuli coagulation disorder. Washed normal platelets resuspended in the patient’s plasma and in adsorbed normal plasma showed a normal aggregation. On the contrary, normal platelets resuspended in normal serum failed to aggregate. These studies indicate that factor X plays no role in normal platelet aggregation.

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