Kinetic characterization of the catalysis of “activated” cyclophosphamide (4-hydroxycyclophosphamide/aldophosphamide) oxidation to carboxyphosphamide by mouse hepatic aldehyde dehydrogenases
- 1 July 1988
- journal article
- research article
- Published by Elsevier in Biochemical Pharmacology
- Vol. 37 (14) , 2781-2790
- https://doi.org/10.1016/0006-2952(88)90041-x
Abstract
No abstract availableThis publication has 17 references indexed in Scilit:
- Liver cytosolic aldehyde dehydrogenases from “alcohol-drinking” and “alcohol-avoiding” mouse strains: purification and molecular propertiesInternational Journal of Biochemistry, 1986
- Aldehyde dehydrogenase activity as the basis for the relative insensitivity of murine pluripotent hematopoietic stem cells to oxazaphosphorinesBiochemical Pharmacology, 1985
- Mouse mitochondrial aldehyde dehydrogenase isozymes: Purification and molecular propertiesInternational Journal of Biochemistry, 1985
- NMR spectroscopic studies of intermediary metabolites of cyclophosphamide. A comprehensive kinetic analysis of the interconversion of cis- and trans-4-hydroxycyclophosphamide with aldophosphamide and the concomitant partitioning of aldophosphamide between irreversible fragmentation and reversible conjugation pathwaysJournal of Medicinal Chemistry, 1984
- Base-catalyzed hydrolysis of 4-hydroperoxycyclophosphamide: evidence for iminocyclophosphamide as an intermediateJournal of Medicinal Chemistry, 1984
- In situ preparation and fate of cis-4-hydroxycyclophosphamide and aldophosphamide: proton and phosphorus-31 NMR evidence for equilibration of cis- and trans-4-hydroxycyclophosphamide with aldophosphamide and its hydrate in aqueous solutionJournal of Medicinal Chemistry, 1984
- Inhibition by cyanamide of 4-hydroxycyclophosphamide/aldophosphamide oxidation to carboxyphosphamideBiochemical Pharmacology, 1981
- Metabolism of 4-hydroxycyclophosphamide/aldophosphamide in vitroBiochemical Pharmacology, 1980
- The problem of specificity and selectivity of alkylating cytostatics; studies on N-2-chloroethylamido-oxazaphosphorinesZeitschrift für Krebsforschung und Klinische Onkologie, 1977
- Statistical estimations in enzyme kineticsBiochemical Journal, 1961