Ruthenium‐Catalyzed Sequential Reactions: Deracemization of Secondary Benzylic Alcohols
- 26 February 2007
- journal article
- research article
- Published by Wiley in Chemistry – An Asian Journal
- Vol. 2 (3) , 393-396
- https://doi.org/10.1002/asia.200600354
Abstract
The deracemization of secondary benzylic alcohols proceeds successfully by a two-step process with the appropriate combination of two different ruthenium complexes for catalysis in the first oxidation and second reduction steps. The sequential catalytic system provides a novel approach to obtaining optically active alcohols, including diols, in high yields with excellent enantioselectivity (up to 95 % ee), in contrast to the conventional kinetic resolution of racemic alcohols.Keywords
This publication has 68 references indexed in Scilit:
- Enantioselective Hydrogenation of Aromatic Ketones Catalyzed by Ru Complexes of Goodwin−Lions-type sp2N/sp3N Hybrid Ligands R-BINAN-R‘-PyJournal of the American Chemical Society, 2006
- Sequential Ru−Pd Catalysis: A Two-Catalyst One-Pot Protocol for the Synthesis of N- and O-HeterocyclesJournal of the American Chemical Society, 2006
- Tandem Catalysis: Generating Multiple Contiguous Carbon−Carbon Bonds through a Ruthenium-Catalyzed Ring-Closing Metathesis/Kharasch AdditionJournal of the American Chemical Society, 2005
- A Domino Sequence Consisting of Insertion, Coupling, Isomerization, and Diels–Alder Steps Yields Highly Fluorescent SpirocyclesAngewandte Chemie International Edition in English, 2004
- Mit einer Insertions‐Kupplungs‐Isomerisierungs‐Diels‐Alder‐Dominosequenz zu fluoreszierenden SpirocyclenAngewandte Chemie, 2004
- Zwei Fliegen mit einer Klappe: Katalyse völlig unterschiedlicher Transformationen im Eintopfverfahren.Angewandte Chemie, 2004
- Oxidative Kinetic Resolution of Racemic Alcohols Catalyzed by Chiral Ferrocenyloxazolinylphosphine−Ruthenium ComplexesThe Journal of Organic Chemistry, 2003
- The Half-sandwich Hydride and 16-Electron Complexes of Rhodium and Iridium Containing (1S,2S)-N-(p-Toluenesulfonyl)-1,2-diphenylethylenediamine: Relevant to the Asymmetric Transfer HydrogenationChemistry Letters, 1998
- Kinetic Resolution of Racemic Secondary Alcohols by RuII‐Catalyzed Hydrogen TransferAngewandte Chemie International Edition in English, 1997
- Kinetische Racematspaltung sekundärer Alkohole durch Ruthenium(II)‐katalysierte TransferhydrierungAngewandte Chemie, 1997