NATURAL-KILLER CELL-ACTIVITY IN ADULT GNOTOBIOTIC DOGS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 44  (4) , 635-638
Abstract
An in vitro assay for natural killer cell activity by canine peripheral blood leukocytes was developed, using 51Cr-labeled heterologous (African green monkey kidney Vero) and homologous (Madin-Darby canine kidney, canine melanoma and canine thyroid adenocarcinoma) target cells. Transformed tumor cell lines proved highly susceptible to natural killer-mediated lysis. Leukocytes from adult gnotobiotic dogs possessed levels of activity comparable to those observed in conventional animals.