Accumulation of ornithine decarboxylase mRNA accompanies activation of human and mouse monocytes/macrophages
Open Access
- 30 July 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 268 (1) , 32-34
- https://doi.org/10.1016/0014-5793(90)80965-l
Abstract
Accumulation of ornithine decarboxylase (ODC) mRNA was investigated in human monocytes and mouse peritoneal macrophages. Treatment of both populations of mononuclear phagocytes with bacterial lipopolysaccharide induced a marked and rapid increase in the accumulation of the ODC gene transcript. A similar phenomenon, albeit less pronounced, was also observed following treatment of human monocytes with human recombinant interferon‐γ. These results suggest a role for ODC, and therefore polyamines, in the regulation of mononuclear phagocyte functions.Keywords
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