ULTRASTRUCTURE OF HEPATOCELLULAR CARCINOMA IN A CIRRHOTIC LIVER

  • 1 January 1977
    • journal article
    • research article
    • Vol. 13  (6) , 590-599
Abstract
Hepatoma cells, though sharing many similarities with non-neoplastic human hepatocytes, showed conspicuous alterations, i.e., increased nuclear/cytoplasmic ratio, intranuclear invaginations of cytoplasm, lipoid material, high mitotic activity and the presence of abundant small fat droplets and glycogen in the cytoplasm. Capillarization of sinusoids was a constant feature with the appearance of junctions between endothelial cells, deposition of fibrillary material in Disse''s spaces, flattening of hepatocyte microvilli and deposition of basement membrane-like material. Abundant microtubules and the presence of annulate lamellae were other features noted in the tumor cells.

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