The Effect of Certain Chelating Compounds on the Urinary Excretion of Copper by the Rat: Observations on their Clinical Significance
- 1 October 1977
- journal article
- research article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 53 (4) , 317-320
- https://doi.org/10.1042/cs0530317
Abstract
A screening procedure is described to assess rapidly the clinical potential of chelating agents for treatment of Wilson''s disease. Compounds investigated were given orally to rats as a standard dose of 100 mg. Cu was determined by atomic absorption spectrophotometry. Basal urine Cu excretion was 65.1 .+-. SE 2.93 nmol/24 h (4.1 .mu.g .+-. 0.185). After penicillamine this rose to 367.1 nmol and after trien [triethylene tetramine] to 305.9 nmol. Certain compounds caused a reduction in the amount of Cu excreted in the urine, probably by forming insoluble chelates with the metal, hence rendering it unavailable for excretion at the glomerulus.This publication has 1 reference indexed in Scilit:
- Metabolic balance studies in hepatolenticular degeneration treated with diethyldithiocarbamateThe American Journal of Medicine, 1963