Influence of two α-Globin Gene Deletions on Homozygous β°-Thalassemia
- 1 January 1982
- journal article
- research article
- Published by Taylor & Francis in Hemoglobin
- Vol. 6 (2) , 115-129
- https://doi.org/10.3109/03630268209002288
Abstract
The favorable influence of α-thalassemia due to a deletion of two α-globin genes (a-thal-1) on homozygous 3°-thalassemia in an adult Chinese woman is described. Her clinical and hematologic condition was milder than usually seen in homozygous β°-thalassemia. With the help of repeated blood transfusions immediately before delivery she gave birth to a physically healthy baby who had the α-thal-1 trait due to two α-globin gene deletions. with Hb Bart's in the cord blood.This publication has 17 references indexed in Scilit:
- Detection of specific sequences among DNA fragments separated by gel electrophoresisPublished by Elsevier ,2006
- Partial deletion of beta-globin gene DNA in certain patients with beta 0-thalassemia.Proceedings of the National Academy of Sciences, 1979
- Identification of a Nondeletion Defect in α-ThalassemiaNew England Journal of Medicine, 1977
- Deletion of α-globin genes in haemoglobin-H disease demonstrates multiple α-globin structural lociNature, 1975
- Nucleotide sequence of the rightward operator of phage lambda.Proceedings of the National Academy of Sciences, 1975
- Gene deletion as the cause of α thalassaemia: Genetic lesion in homozygous α thalassaemia (hydrops fetalis)Nature, 1974
- Gene deletion as the cause of α thalassaemia: The severe form of α thalassaemia is caused by a haemoglobin gene deletionNature, 1974
- Abnormal human haemoglobins: Separation and characterization of the α and β chains by chromatography, and the determination of two new variants, Hb chesapeake and Hb J (Bangkok)Journal of Molecular Biology, 1966
- Hæmoglobin H Disease in Thailand: a Genetical StudyNature, 1964
- Alpha-chain Thalassemia and Hydrops Fetalis in Malaya: Report of Five CasesBlood, 1962