Studies on the noncooperative binding of the Escherichia coli DNA unwinding protein to single-stranded nucleic acids

Abstract
The noncooperative binding of the E. coli DNA unwinding protein to single-stranded DNA oligomers was studied by equilibrium dialysis. Dialyses were performed under a number of solution and temperature conditions using oligomers of varying length and base composition. From Scatchard analysis of the binding and other results, a model for the cooperative binding of the proteins to single-stranded DNA is proposed. The interaction of the protein with single-stranded RNA is also presented.

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