Strontium-calcium interrelationships in the growing rat

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Abstract
The comparative metabolic behavior of strontium and calcium was studied in growing, female rats exposed either continuously or to single doses of Sr90 and Ca45 while on diets of various total calcium contents. At weaning the discrimination against ingested Sr90 relative to Ca45 was markedly less than that previously observed in mature rats. This discrimination increased and approached the levels observed in mature animals, while growth and Ca45 deposition was still proceeding at a rapid rate. The effect of a fourfold increase in dietary calcium (from 0.5 to 2.0%) over a 200-day feeding period was a twofold reduction in the steady-state level of Sr90 in bone. As previously shown in mature rats, the retention (as opposed to absorption) of a single dose of Sr90 was relatively unaffected by dietary calcium level, while that of Ca45 varied from almost total retention on a 0.1% calcium diet to retention on a 2.0% calcium diet which was similar to that observed for Sr90 on all diets.

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