EFFECT OF TESTOSTERONE PROPIONATE ON THE PROSTATE GLAND OF PATIENTS OVER 45*

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Abstract
One hundred men over 45 years of age, previously treated for periods up to 5 years with amounts of testosterone propionate not exceeding 5200 mg, were examined and the incidence of prostatic abnormalities compared with that in 100 controls. In 32 patients of the treated group, prostatic abnormalities had developed, but similar abnormalities had occurred in 39 of the control group. Twenty-seven treated patients showed prostatic hypertrophy, but 34 control subjects also had an enlarged prostate. Palpable prostatic irregularities occurred in 11 treated patients versus 13 control subjects. Carcinoma of the prostate was found only once[long dash]in an 80-year-old patient of the treated group, 7 years after treatment was terminated. In this study, there was no evidence that testosterone propionate in the dosage used had initiated carcinoma or activated latent carcinoma of the prostate gland.

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