Structure/function in neuroprotection and apoptosis

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Abstract
The three‐dimensional conformation of proteins influences their potential to function correctly within the cell. Protein conformational issues are particularly important in neurodegeneration, as has been shown by misfolded protein forming the basis of plaques in Alzheimer's disease and prion diseases. This article focuses on protein structure/function specifically for proteins important in the pathogenesis of neurodegenerative conditions and those involved in apoptosis. The proteins used as examples in this review include α‐synuclein, the promyelocytic leukemia protein, and glyceraldehyde 3‐phosphate dehydrogenase.

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