Pituitary and Plasma Bioassay for Trophic Hormones in the Alloxan-Diabetic Rat.

Publisher Website
Google Scholar
Abstract
The gonadotropic, thyrotropic, and growth hormone content of anterior pituitaries from female rats rendered diabetic by alloxan at 50 days of age was determined 50 days later by bioassay in hypophysectomized 26-28 day female rats, 14 days postoperative, using 8 rats for each dose level. Comparisons were made with pituitaries from normal rats of the same size. Trophic hormones in blood plasma were also determined, using 3 to 4 rats for each dose level. The number of glands required to evoke minimum follicle stimulating, interstitial cell stimulating, and thyrotropic activity were the same in diabetic and normal rats, whereas growth hormone content of the pituitary was reduced 16-fold. The titer of circulating growth promoting factors was also reduced.

This publication has 6 references indexed in Scilit: