ACTION OF NEURO-PHARMACOLOGIC AGENTS ON BLADDER AND URETHRA DURING EXPERIMENTAL SPINAL SHOCK

  • 1 January 1977
    • journal article
    • research article
    • Vol. 14  (4) , 312-316
Abstract
Pressure recordings within the bladder, proximal (U1) and middle (U2) thirds of the urethra were monitored in anesthetized female mongrel dogs before and just after being made paraplegic, i.e., during the period of spinal shock. In the intact animal, parasympathetic stimulation produced uninhibited waves whereas U2 pressure remained unchanged; during spinal shock, it produced a small rise of intravesical pressure, without uninhibited waves but with a marked increase in U2 pressure. This may explain why bethanechol chloride was not effective in producing bladder emptying during spinal shock. Stimulation of the .beta.-receptors of the sympathetic nervous system and blockage of the .alpha.-receptors both singly and in combination produce urethral sphincter relaxation during spinal shock. This may allow bladder evacuation during spinal shock with the Crede maneuver or abdominal straining.

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