Characterisation of mouse monoclonal antibodies produced by immunisation with a single serotype component of a polyvalent Pseudomonas aeruginosa vaccine
- 1 February 1986
- journal article
- research article
- Published by Microbiology Society in Journal of Medical Microbiology
- Vol. 21 (1) , 87-90
- https://doi.org/10.1099/00222615-21-1-87
Abstract
Mouse monoclonal antibodies raised by immunisation with a protective antigen extract from Pseudomonas aeruginosa serotype 1 varied in immunoglobulin isotype, in passive protective properties against infection by homologous P. aeruginosa serotype 1, and in cross-reactions in ELISA against antigen preparations from 15 other P. aeruginosa serotypes. All monoclonal antibodies with specificity in ELISA for the immunising antigen gave some degree of protection to mice against lethal infection by the homologous P. aeruginosa serotype. The IgG antibodies were more protective than the IgM antibodies.This publication has 3 references indexed in Scilit:
- An investigation of the use of urease-antibody conjugates in enzyme immunoassaysJournal of Immunological Methods, 1982
- Antibody responses of burned patients immunized with a polyvalent Pseudomonas vaccineEpidemiology and Infection, 1979
- A New Polyvalent Pseudomonas VaccineJournal of Medical Microbiology, 1977