Measurement of prostaglandins E and F in the uterine tissue and uterine fluid of ovariectomized rats treated with various doses of oestradiol-17
- 1 September 1977
- journal article
- research article
- Published by Bioscientifica in Reproduction
- Vol. 51 (1) , 119-121
- https://doi.org/10.1530/jrf.0.0510119
Abstract
Treatment with estradiol caused a significant increase (P < 0.05) in concentrations of PG[prostaglandin]E and PGF in uterine tissue compared with values in control animals. Amounts of PGE in uterine tissue homogenates were substantially lower than those of PGF, and although this difference was evident in all animals studied, the ratio between PGE and PGF was the greatest in the control group. No uterine fluid could be obtained from uteri of untreated rats or those treated with 0.4 .mu.g estradiol-17.beta.. The volume of uterine fluid obtained from rats treated with 2 .mu.g estradiol did not differ significantly (P < 0.05) from that in rats treated with higher doses. Concentrations of PGE in uterine fluid were substantially higher than those of PGF. Formation of these PG in the uterine tissue and in the intraluminal environment of the uterus in different proportions may be a mechanism for controlling permeability changes in the uterus at the time of implantation. Differential release of PG in response to the estrogen surge in the pregnant animal may be part of the mechanism of implantation in this species.Keywords
This publication has 1 reference indexed in Scilit:
- In vitro production of prostaglandins E and F by the guinea pig ovarian tissueProstaglandins, 1976