The effects of multiple low doses of organophosphates on target enzymes in brain and diaphragm in the mouse
- 1 February 1997
- journal article
- research article
- Published by SAGE Publications in Human & Experimental Toxicology
- Vol. 16 (2) , 67-71
- https://doi.org/10.1177/096032719701600201
Abstract
1 Multiple low doses of the direct acting organopho sphates, ecothiopate, paraoxon and mipafox produced persistent and additive inhibition of diaphragm acetylcholinesterase. Paraoxon and mipafox had similar effects on brain acetylcholinesterase. There was greater recovery from inhibition between doses for paraoxon and ecothiopate than for mipafox.2 Ecothiopate did not inhibit brain acetylcholinesterase but there was a small increase in activity.3 Mipafox also had a cumulative inhibitory effect on brain neuropathy target esterase.4 These results have particular implication for the use of multiple low doses of organophosphates occupation- ally by man.Keywords
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