Mifepristone (RU 486)

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Abstract
In the evolution of eutherian mammals (species that gestate their young in utero), the stimulatory effect on the uterus of progesterone, a steroid hormone present in all vertebrates, was a critical adaptation. Half a century ago, the distinguished French endocrinologist Robert Courrier explained its importance succinctly: "Progesterone is the hormone of the mother, it is indispensable for reproduction" (Biologie des Hormones Sexuelles Femelles, 1937). Simply stated, pregnancy cannot be established and maintained without the stimulatory effect of progesterone on endometrial growth and its inhibitory effect on myometrial contractility, because both actions of the hormone are required for the . . .

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