Checkpoint control of mitotic exit—do budding yeast mind the GAP?
Open Access
- 23 January 2006
- journal article
- editorial
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 172 (3) , 331-333
- https://doi.org/10.1083/jcb.200512153
Abstract
Cell cycle checkpoints can delay mitotic exit in budding yeast. The master controller is the small GTPase Tem1, with inputs from a proposed guanine nucleotide exchange factor (GEF), Lte1, and a GTPase-activating protein (GAP), Bub2/Bfa1. In this issue, Fraschini et al. (p. 335) show that GAP activity of Bub2/Bfa1 appears to be dispensable for inactivation of Tem1 in cells. Their results call into question the GTP/GDP switch model for Tem1 activity, as have other results in the past. The paper also focuses attention on the two spindle pole bodies as potential sites for regulation of Tem1.Keywords
This publication has 20 references indexed in Scilit:
- Disappearance of the budding yeast Bub2–Bfa1 complex from the mother-bound spindle pole contributes to mitotic exitThe Journal of cell biology, 2006
- Septins Have a Dual Role in Controlling Mitotic Exit in Budding YeastCurrent Biology, 2003
- Spatial regulation of the guanine nucleotide exchange factor Lte1 inSaccharomyces cerevisiaeJournal of Cell Science, 2002
- A role for cell polarity proteins in mitotic exitThe EMBO Journal, 2002
- Control of Mitotic Exit in Budding YeastPublished by Elsevier ,2002
- Separase, Polo Kinase, the Kinetochore Protein Slk19, and Spo12 Function in a Network that Controls Cdc14 Localization during Early AnaphaseCell, 2002
- Modes of spindle pole body inheritance and segregation of the Bfa1p-Bub2p checkpoint protein complexThe EMBO Journal, 2001
- Anaphase spindle position is monitored by the BUB2 checkpointNature Cell Biology, 2000
- A Mechanism for Coupling Exit from Mitosis to Partitioning of the NucleusCell, 2000
- The Bub2p Spindle Checkpoint Links Nuclear Migration with Mitotic ExitMolecular Cell, 2000