The Structure of Fowl Plague Virus and Virus N

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Abstract
Fowl plague (KP) virus and virus N have been examined in the electron microscope as both metal shadowed and negatively stained preparations. The particles of KP virus are very similar to those of influenza A. The products of ether splitting are (1) the G antigen, a ribonucleoprotein whose helically arranged protein subunits can be resolved and (2) the haemagglutinin, a star-shaped structure about 350 A diameter made up of the spikes which project from the surface of the intact particle. Incomplete forms have been prepared by serial undiluted passage, and these show great pleomorphism, but the same outer coat as complete virus. Ether splitting of incomplete forms yields a haemagglutinin like that from complete virus, but only traces of G antigen. Virus N is more pleomorphic than KP virus, but the products of ether splitting are very similar.

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